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Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.

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第一作者: Fulya,Akçimen
第一单位: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
作者: Fulya,Akçimen [1] ; Kimberly,Paquette [2] ; Peter Wild,Crea [3] ; Paula,Saffie-Awad [4] ; Charles,Achoru [5] ; Funmilola,Taiwo [6] ; Simon,Ozomma [7] ; Gerald,Onwuegbuzie [8] ; Marzieh,Khani [2] ; Spencer,Grant [3] ; Lukman,Owolabi [9] ; Chiamaka,Okereke [10] ; Olajumoke,Oshinaike [11] ; Emmanuel,Iwuozo [12] ; Paul Suhwan,Lee [1] ; Shyngle,Oyakhire [13] ; Nosakhare,Osemwegie [14] ; Kensuke,Daida [15] ; Sani,Abubakar [16] ; Adedunni,Olusanya [17] ; Mariam,Isayan [18] ; Rami,Traurig [2] ; Adebimpe,Ogunmodede [19] ; Sarah,Samuel [20] ; Mary B,Makarious [21] ; Fadimatu,Sa'ad [22] ; Rashidat,Olanigan [23] ; Kristin,Levine [21] ; Ewere Marie,Ogbimi [24] ; Dan,Vitale [21] ; Francis,Odiase [25] ; Mathew J,Koretsky [21] ; Francis,Ojini [26] ; Olanike,Odeniyi [27] ; Zih-Hua,Fang [28] ; Nkechi,Obianozie [29] ; Deborah A,Hall [30] ; Ernest,Nwazor [31] ; Tao,Xie [32] ; Francisca,Nwaokorie [33] ; Mahesh,Padmanaban [32] ; Paul,Nwani [34] ; Ejaz A,Shamim [35] ; Alero,Nnama [14] ; David,Standaert [36] ; Morenikeji,Komolafe [37] ; Marissa,Dean [36] ; Godwin,Osaigbovo [5] ; Elizabeth,Disbrow [38] ; Ismaila,Ishola [33] ; Ashley,Rawls [39] ; Frank,Imarhiagbe [25] ; Shivika,Chandra [40] ; Cyril,Erameh [41] ; Vanessa,Hinson [42] ; Naomi,Louie [43] ; Ahmed,Idowu [44] ; J,Solle [43] ; Scott A,Norris [45] ; Abdullahi,Ibrahim [46] ; Camilla,Kilbane [47] ; Gauthaman,Sukumar [48] ; Lisa M,Shulman [49] ; Daniel,Ezuduemoih [50] ; Julia,Staisch [51] ; Sarah,Breaux [51] ; Clifton,Dalgard [52] ; Erin R,Foster [45] ; Abiodun,Bello [53] ; Andrew,Ameri [42] ; Raquel,Real [54] ; Erica,Ikwenu [50] ; Huw R,Morris [55] ; Roosevelt,Anyanwu [33] ; Erin Furr,Stimming [40] ; Kimberley,Billingsley [2] ; Wemimo,Alaofin [56] ; Pilar Alvarez,Jerez [57] ; Osigwe,Agabi [26] ; Dena G,Hernandez [1] ; Rufus,Akinyemi [58] ; Sampath,Arepalli [1] ; Laksh,Malik [2] ; Raymond,Owolabi [19] ; Yakub,Nyandaiti [20] ; Hampton L,Leonard [21] ; Kolawole,Wahab [56] ; Kathryn,Step [59] ; Oladunni,Abiodun [60] ; Carlos F,Hernandez [61] ; Fatima,Abdulai [29] ; Hirotaka,Iwaki [21] ; Soraya,Bardien [59] ; Christine,Klein [62] ; John,Hardy [63] ; Henry,Houlden [64] ; Kamalini Ghosh,Galvelis [65] ; Mike A,Nalls [21] ; Nabila,Dahodwala [66] ; Whitley,Aamodt [66] ; Emily,Hill [67] ; Alberto,Espay [67] ; Stewart,Factor [68] ; Chantale,Branson [69] ; Cornelis,Blauwendraat [3] ; Andrew B,Singleton [3] ; Oluwadamilola,Ojo [26] ; Lana M,Chahine [70] ; Black and African American Connections to Parkinson’s Disease Study (BLAAC PD) [26] ; Nigeria Parkinson’s Disease Research Network (NPDRN) [2] ; Racial Disparities in Parkinson Disease (RaD-PD) ; Global Parkinson’s Genetics Program (GP2) ; Njideka,Okubadejo ; Sara,Bandres-Ciga
作者单位: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. [1] Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. [2] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.;Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. [3] Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.;Clínica Santa María, Santiago, Chile. [4] Jos University Teaching Hospital, Jos, Plateau State, Nigeria. [5] University College Hospital, Ibadan, Oyo State, Nigeria. [6] University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria. [7] University of Abuja, Abuja, Federal Capital Territory, Nigeria. [8] Bayero University, Kano, Kano State, Nigeria. [9] University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria. [10] Lagos State University College Of Medicine, Ikeja, Lagos State, Nigeria. [11] Benue State University, Makurdi, Benue State, Nigeria. [12] National Hospital Abuja, Federal Capital Territory, Nigeria. [13] University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. [14] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.;Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.;Department of Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan. [15] Ahmadu Bello University, Zaria, Kaduna State, Nigeria. [16] College of Medicine, University of Lagos, Idi-araba, Lagos State, Nigeria.;R-Jolad Hospital, Gbagada, Lagos, Nigeria. [17] Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia. [18] Federal Medical Center, Owo, Ondo State, Nigeria. [19] University of Maiduguri Teaching Hospital, Maiduguri, Borno State. [20] Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.;DataTecnica LLC, Washington, DC, USA. [21] Federal Teaching Hospital, Gombe, Gombe State, Nigeria. [22] Lagos State University Teaching Hospital, Ikeja, Lagos State, Nigeria. [23] Delta State University, Abraka, Delta State, Nigeria. [24] University of Benin, Benin City, Edo State, Nigeria. [25] College of Medicine, University of Lagos, Idi-araba, Lagos State, Nigeria.;Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria. [26] General Hospital, Lagos Island, Lagos State, Nigeria. [27] German Center for Neurodegenerative Diseases, DZNE, Tübingen, Germany. [28] University of Abuja Teaching Hospital, Gwagwalada, Federal Capital Territory, Nigeria. [29] Department of Neurological Sciences, Rush University Medical Center, Chicago, USA. [30] Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria. [31] University of Chicago Medicine, Department of Neurology, Chicago, USA. [32] College of Medicine, University of Lagos, Idi-araba, Lagos State, Nigeria. [33] Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria. [34] National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.;Mid-Atlantic Permanente Medical Group, Department of Neurology, Largo, MD, USA.;Kaiser Permanente, MidAtlantic Permanente Research Institute, Washington, DC, USA. [35] University of Alabama at Birmingham, Department of Neurology, Birmingham, USA. [36] Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. [37] Department of Neurology, LSU Health Shreveport, LSU Health Shreveport Center for Brain Health, Shreveport, USA. [38] University of Florida Norman Fixel Institute for Neurological Diseases, Neurology Movement Disorders, Gainesville, USA. [39] The University of Texas Health Science Center at Houston, Houston, TX, USA. [40] Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria. [41] Medical University of South Carolina, Charleston, SC, USA. [42] Michael J. Fox Foundation for Parkinson's Research, Department of Clinical Research, New York, USA. [43] Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria. [44] Washington University in St. Louis, St. Louis, MO, USA. [45] Federal University of Health Sciences Teaching Hospital, Azare, Bauchi State, Nigeria. [46] University Hospital in Cleveland Medical Center/Case Western Reserve University (UH). [47] Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services.;University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, 20814, USA. [48] University of Maryland, Baltimore, MD, USA. [49] Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria. [50] Ochsner Clinic Foundation, New Orleans, LA, USA. [51] Henry M. Jackson Foundation for the Advancement of Military Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.;The American Genome Center, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. [52] University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria. [53] Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.;UCL Movement Disorders Centre, University College London, London WC1N 3BG, UK. [54] Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.;National Hospital for Neurology and Neurosurgery, London, UK.;Department of Neurology, Royal Free Hospital, London, UK. [55] University of Ilorin, Ilorin, Kwara State, Nigeria. [56] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.;Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK. [57] Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. [58] Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. [59] General Hospital, Isolo, Lagos State, Nigeria. [60] Universidad del Desarrollo, Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana, Santiago 7610658, Chile. [61] Institute of Neurogenetics and Department of Neurology, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany. [62] Reta Lila Weston Institute, University College London Institute of Neurology, Queen Square, London, UK. [63] Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK. [64] Parkinson's Foundation, NewYork, NY 10018, USA. [65] University of Pennsylvania, Philadelphia, PA. [66] University of Cincinnati, Cincinnati, Ohio. [67] Emory University, Atlanta, GA. [68] Morehouse College, Atlanta, GA. [69] University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA. [70]
DOI 10.1101/2025.01.14.25320205
PMID 39867380
发布时间 2025-10-14
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