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Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates.

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第一作者: Marina,Able
第一单位: Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.
作者单位: Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany. [1] Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin, Berlin, Germany.;Department of Chemistry, Humboldt Universität zu Berlin, Berlin, Germany.;Tubulis GmbH, Munich, Germany. [2] German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.;Research Unit Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany. [3] Faculty of Biology, Human Biology and BioImaging, LMU Munich, Planegg-Martinsried, Germany. [4] Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany. [5] Tubulis GmbH, Munich, Germany. [6] Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.;German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.;German Cancer Research Center (DKFZ), Heidelberg, Germany. [7] Technical University of Munich School of Medicine and Health, Department of Medicine III, Technical University of Munich (TUM), Munich, Germany. [8] Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin, Berlin, Germany.;Tubulis GmbH, Munich, Germany. [9] Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin, Berlin, Germany. [10] Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.;German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany. [11] Tubulis GmbH, Munich, Germany.;Faculty of Biology, Human Biology and BioImaging, LMU Munich, Planegg-Martinsried, Germany. [12] Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin, Berlin, Germany.;Department of Chemistry, Humboldt Universität zu Berlin, Berlin, Germany. [13] German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.;Technical University of Munich School of Medicine and Health, Department of Medicine III, Technical University of Munich (TUM), Munich, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany. [14] German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.;Research Unit Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany.;Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU, Munich, Germany. [15] Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany. karsten.spiekermann@med.uni-muenchen.de.;German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany. karsten.spiekermann@med.uni-muenchen.de.;Bavarian Cancer Research Center (BZKF), Munich, Germany. karsten.spiekermann@med.uni-muenchen.de. [16]
DOI 10.1038/s41375-024-02510-5
PMID 39870768
发布时间 2025-05-04
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