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Synthesis and biological investigation of peptidomimetic SARS-CoV-2 main protease inhibitors bearing quinoline-based heterocycles at P<sub>3</sub>.

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第一作者： Sara,Rossi

第一单位： Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.

作者： Sara,Rossi ^[1] ; Graziano,Deidda ^[2] ; Lia,Fiaschi ^[3] ; Roberta,Ibba ^[1] ; Mariachiara,Pieroni ^[1] ; Maria,Dichiara ^[1] ; Gabriele,Carullo ^[1] ; Stefania,Butini ^[1] ; Anna,Ramunno ^[4] ; Simone,Brogi ^[5] ; Marco,Lolicato ^[6] ; Cristina,Arrigoni ^[6] ; Noemi,Cabella ^[2] ; Laura,Bavagnoli ^[2] ; Giovanni,Maga ^[2] ; Ilenia,Varasi ^[3] ; Camilla,Biba ^[3] ; Ilaria,Vicenti ^[3] ; Sandra,Gemma ^[1] ; Emmanuele,Crespan ^[2] ; Maurizio,Zazzi ^[3] ; Giuseppe,Campiani ^[1]

作者单位： Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy. ^[1] Institute of Molecular Genetics IGM-CNR 'Luigi Luca Cavalli-Sforza', Pavia, Italy. ^[2] Department of Medical Biotechnologies, University of Siena, Siena, Italy. ^[3] Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy. ^[4] Department of Pharmacy, University of Pisa, Pisa, Italy. ^[5] Department of Molecular Medicine, University of Pavia, Pavia, Italy. ^[6]

关键词 SARS‐CoV‐2 X‐ray crystallography live virus antiviral assay main protease peptidomimetics