Glucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies.

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作者： Li,Li ^[1] ; Mei,Luo ^[1] ; Lifang,Zhou ^[1] ; Yanhong,Wang ^[1] ; Yaoge,Jiao ^[1] ; Chunting,Wang ^[1] ; Changyang,Gong ^[1] ; Xiaobo,Cen ^[2] ; Shaohua,Yao ^[3]

作者单位： Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Renmin Nanlu 17, Chengdu 610041, Sichuan, China. ^[1] Mental Health Center and Center for Preclinical Safety Evaluation of Drugs, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, China. Electronic address: xbcen@scu.edu.cn. ^[2] Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Renmin Nanlu 17, Chengdu 610041, Sichuan, China. Electronic address: shaohuayao@scu.edu.cn. ^[3]

关键词 Genome editing Glucocorticoid Lipid nanoparticles Macrophage Protein replacement mRNA therapy

DOI 10.1016/j.ijpharm.2025.125282

PMID 39880143

发布时间 2025-02-05

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International journal of pharmaceutics

2025年672卷

125282页

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Glucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies.

International journal of pharmaceutics

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International journal of pharmaceutics

相关期刊

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Glucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies.

International journal of pharmaceutics

相似文献

International journal of pharmaceutics

相关期刊

检索历史清除