Elevated protein lactylation promotes immunosuppressive microenvironment and therapeutic resistance in pancreatic ductal adenocarcinoma.
第一作者:
Kang,Sun
第一单位:
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine and.;Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.;MOE Joint International Research Laboratory of Pancreatic Diseases, Hangzhou, China.;Zhejiang Provincial Clinical Research Center for the Study of Hepatobiliary & Pancreatic Diseases, Zhejiang University, Hangzhou, China.
作者:
医学主题词
癌, 胰腺管(Carcinoma, Pancreatic Ductal);人类(Humans);肿瘤微环境(Tumor Microenvironment);胰腺肿瘤(Pancreatic Neoplasms);小鼠(Mice);动物(Animals);抗药性, 肿瘤(Drug Resistance, Neoplasm);细胞系, 肿瘤(Cell Line, Tumor);STAT3转录因子(STAT3 Transcription Factor);趋化因子CCL2(Chemokine CCL2);肿瘤蛋白质类(Neoplasm Proteins);女(雌)性(Female);乳酸(Lactic Acid)
DOI
10.1172/JCI187024
PMID
39883522
发布时间
2025-05-04
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