Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF-1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide.

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作者： Katarina,Milosevic ^[1] ; Ana,Milosevic ^[1] ; Ivana,Stevanovic ^[2] ; Anica,Zivkovic ^[1] ; Danijela,Laketa ^[3] ; Marija M,Janjic ^[1] ; Ivana,Bjelobaba ^[1] ; Irena,Lavrnja ^[1] ; Danijela,Savic ^[1]

作者单位： Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic"-National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia. ^[1] Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Belgrade, Serbia. ^[2] Department for General Physiology and Biophysics, Faculty of Biology, University of Belgrade, Belgrade, Serbia. ^[3]

关键词 ATP HIF‐1α PI3K/Akt/mTOR agmatine glycolysis microglia

主题词小神经胶质细胞(Microglia);脂多糖类(Lipopolysaccharides);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);糖酵解(Glycolysis);动物(Animals);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);小鼠(Mice);信号传导(Signal Transduction);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);线粒体(Mitochondria);胍丁胺(Agmatine);细胞系(Cell Line);膜电位, 线粒体(Membrane Potential, Mitochondrial)

DOI 10.1002/biof.2149

PMID 39888089

发布时间 2025-02-04

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Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF-1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide.

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Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF-1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide.

BioFactors (Oxford, England)

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