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Cryo-ET suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules.

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第一作者： Saikat,Chakraborty

第一单位： Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

作者： Saikat,Chakraborty ^[1] ; Antonio,Martinez-Sanchez ^[2] ; Florian,Beck ^[3] ; Mauricio,Toro-Nahuelpan ^[4] ; In-Young,Hwang ^[5] ; Kyung-Min,Noh ^[5] ; Wolfgang,Baumeister ^[1] ; Julia,Mahamid ^[6]

作者单位： Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany. ^[1] Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.;Institute of Neuropathology and Cluster of Excellence "Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells", University Medical Center Göttingen, Göttingen 37075, Germany. ^[2] Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.;Research group CryoEM Technology, Max Planck Institute of Biochemistry, Martinsried 82152, Germany. ^[3] Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany. ^[4] Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany. ^[5] Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.;Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany. ^[6]

关键词 hiPSC-derived neurons in situ cryoelectron tomography microtubule lattice damage primary neurons subtomogram averaging