首页> Frontiers in immunology> Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies.

Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies.

导出 LinkOut

翻译打印收藏纠错

第一作者： Apolline,Lefèvre

第一单位： Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences PS, Roche Innovation Center Basel, Basel, Switzerland.;Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.

作者： Apolline,Lefèvre ^[1] ; Zinnia P,Parra-Guillen ^[2] ; Iñaki F,Trocóniz ^[3] ; Christophe,Boetsch ^[4] ; Nicolas,Frances ^[4]

作者单位： Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences PS, Roche Innovation Center Basel, Basel, Switzerland.;Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain. ^[1] Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. ^[2] Pharmacometrics & Systems Pharmacology, Department of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.;Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.;Institute of Data Science and Artificial Intelligence (DATAI), University of Navarra, Pamplona, Spain. ^[3] Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences PS, Roche Innovation Center Basel, Basel, Switzerland. ^[4]

关键词 T-cell engager (TCE)cancer immunotherapy (CIT)cytokine release effector T-cell dynamics pharmacokinetics/pharmacodynamics (PK/PD) modeling

医学主题词人类(Humans);细胞因子类(Cytokines);T淋巴细胞(T-Lymphocytes);肿瘤(Neoplasms);免疫疗法(Immunotherapy);模型, 免疫学(Models, Immunological)

DOI 10.3389/fimmu.2024.1463915

PMID 39896804

发布时间 2026-05-19

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交