Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold.

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作者： Xiaoyu,Wan ^[1] ; Jiajun,Yap ^[2] ; Junjun,Chen ^[1] ; Yifan,Li ^[1] ; Regina,Faruk ^[1] ; Nazereth Chor Boon,Tan ^[1] ; Yiying,Ma ^[1] ; Yiting,Lim ^[1] ; Karlina Bte,Jubri ^[1] ; Jingyi,Hu ^[1] ; Jimin,Yuan ^[1] ; Ge,Zhang ^[1] ; Quan,Li ^[1] ; Yoon Sim,Yap ^[3] ; Paula,Lam ^[4] ; Mei,Wang ^[5] ; Nai Yang,Fu ^[6] ; Jiancheng,Hu ^[2]

作者单位： The Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore General Hospital, 30 Hospital Boulevard, Singapore 168583. ^[1] The Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore General Hospital, 30 Hospital Boulevard, Singapore 168583.;The Cancer and Stem Cell Program, Duke-NUS Medical School, 8 College Road, Singapore 169857. ^[2] The Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583.;The Oncology Academic Clinical Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857. ^[3] The Cancer and Stem Cell Program, Duke-NUS Medical School, 8 College Road, Singapore 169857.;Department of Physiology, National University of Singapore, 2 Medical Drive, Singapore 117597.;Cellvec Pte. Ltd. 100 Pasir Panjang Road, Singapore 118518. ^[4] The Cancer and Stem Cell Program, Duke-NUS Medical School, 8 College Road, Singapore 169857. ^[5] The Cancer and Stem Cell Program, Duke-NUS Medical School, 8 College Road, Singapore 169857.;ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia. ^[6]

关键词 14-3-3 scaffold BRAF Cdc37/Hsp90 chaperone Oncogenic mutations RAF family kinases RAS/RAF/MEK/ERK signaling Targeted cancer therapy