首页> BMJ open> Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer.

Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort, with economic evaluation, process evaluation and qualitative sub-study, to explore the natural history of LARS and compare transanal irrigation and sacral neuromodulation to optimised conservative management for people with major LARS following a high or low anterior resection for colorectal cancer.

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第一作者： Julie,Croft

第一单位： Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.

作者： Julie,Croft ^[1] ; Emily,Farrow ^[2] ; Alexandra Harriet,Coxon-Meggy ^[3] ; Katie,Gordon ^[1] ; Neil,Corrigan ^[1] ; Hannah,Mather ^[1] ; Deborah D,Stocken ^[1] ; Megan,Dale ^[4] ; Huey Yi,Chong ^[4] ; Judith,White ^[5] ; Laura,Knight ^[5] ; Alun,Meggy ^[6] ; Christina,Lloydwin ^[7] ; Betty,Tan ^[8] ; Ashley,Douglas ^[8] ; Ralph,Powell ^[9] ; Julie,Hepburn ^[9] ; David,Jayne ^[10] ; Jared,Torkington ^[3] ; Andrea,Warwick ^[11] ; Kheng-Seong,Ng ^[12] ; Kate,Wilson ^[13] ; Charles H,Knowles ^[14] ; Aaron,Quyn ^[15] ; Julie,Cornish ^[16]

作者单位： Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. ^[1] School of Medicine, Cardiff University, Cardiff, UK.;Colorectal Surgery, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, UK. ^[2] Colorectal Surgery, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff, UK. ^[3] Cardiff and Vale University Health Board, Cardiff, UK. ^[4] CEDAR, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK. ^[5] Research and Development, Cardiff and Vale University Health Board, Cardiff, UK. ^[6] Cwm Taf Morgannwg University Health Board, Abercynon, UK. ^[7] NHMRC Clinical Trials Centre, University of Sydney CAR, Glebe, New South Wales, Australia. ^[8] Involving People Wales, Health and Care Research Wales, Cardiff, UK. ^[9] Department of Colorectal Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK. ^[10] Department of Colorectal Surgery, QEII Jubilee Hospital, Acacia Ridge, Queensland, Australia.;Department of Colorectal Surgery, Royal Brisbane and Woman's Hospital Health Service District, Herston, Queensland, Australia. ^[11] Department of Colorectal Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.;Department of Colorectal Surgery, Concord Repatriation General Hospital, Concord, New South Wales, Australia. ^[12] Central Clinical School, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia.;Surgical Outcomes Research Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. ^[13] Centre for Academic Surgery, Barts and The London School of Medicine and Dentistry Blizard Institute, London, UK. ^[14] Consultant Colorectal Surgeon, Leeds Teaching Hospitals NHS Trust Centre for Respiratory Medicine, Leeds, UK.;Early Years Consultant Network, The Association of Coloproctology of Great Britain and Ireland, London, UK. ^[15] Cardiff and Vale University Health Board, Cardiff, UK julie.cornish@wales.nhs.uk. ^[16]

关键词 Clinical Trial Colorectal surgery Quality of Life