首页> Small (Weinheim an der Bergstrasse, Germany)> A Novel Multicompartment Barrier-Free Microfluidic Device Reveals the Impact of Extracellular Matrix Stiffening and Temozolomide on Immune-Tumor Interactions in Glioblastoma.

A Novel Multicompartment Barrier-Free Microfluidic Device Reveals the Impact of Extracellular Matrix Stiffening and Temozolomide on Immune-Tumor Interactions in Glioblastoma.

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第一作者： Clara,Bayona

第一单位： Tissue Microenvironment (TME) Lab, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, 50018, Spain.;Institute for Health Research Aragón (IIS Aragón), Zaragoza, 50009, Spain.

作者： Clara,Bayona ^[1] ; Claudia,Olaizola-Rodrigo ^[2] ; Vira,Sharko ^[1] ; Mehran,Ashrafi ^[1] ; Jesús Del,Barrio ^[3] ; Manuel,Doblaré ^[4] ; Rosa,Monge ^[5] ; Ignacio,Ochoa ^[4] ; Sara,Oliván ^[1]

作者单位： Tissue Microenvironment (TME) Lab, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, 50018, Spain.;Institute for Health Research Aragón (IIS Aragón), Zaragoza, 50009, Spain. ^[1] Tissue Microenvironment (TME) Lab, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, 50018, Spain.;BEOnChip S.L., Zaragoza, 50018, Spain. ^[2] Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain. ^[3] Tissue Microenvironment (TME) Lab, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, 50018, Spain.;Institute for Health Research Aragón (IIS Aragón), Zaragoza, 50009, Spain.;Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-University of Zaragoza, Department of Organic Chemistry, Zaragoza, 50009, Spain. ^[4] BEOnChip S.L., Zaragoza, 50018, Spain. ^[5]

关键词 barrier‐free biomimetic models extracellular matrix glioblastoma immune system microfluidics temozolomide tumor microenvironment

医学主题词胶质母细胞瘤(Glioblastoma);细胞外基质(Extracellular Matrix);人类(Humans);芯片实验室装置(Lab-On-A-Chip Devices);肿瘤微环境(Tumor Microenvironment);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement)

DOI 10.1002/smll.202409229

PMID 39901479

发布时间 2025-05-05

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