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Successes and failures: the latest advances in the clinical development of amyloid-β-targeting monoclonal antibodies for treating Alzheimer's disease.

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第一作者： Francesco,Panza

第一单位： "Cesare Frugoni" Internal and Geriatric Medicine and Memory Unit, University of Bari "Aldo Moro", Bari, Italy.

作者： Francesco,Panza ^[1] ; Vittorio,Dibello ^[2] ; Rodolfo,Sardone ^[3] ; Roberta,Zupo ^[4] ; Fabio,Castellana ^[4] ; Ivana,Leccisotti ^[5] ; Maria Claudia,Moretti ^[5] ; Mario,Altamura ^[5] ; Antonello,Bellomo ^[5] ; Antonio,Daniele ^[6] ; Vincenzo,Solfrizzi ^[1] ; Emanuela,Resta ^[7] ; Madia,Lozupone

作者单位： "Cesare Frugoni" Internal and Geriatric Medicine and Memory Unit, University of Bari "Aldo Moro", Bari, Italy. ^[1] "Cesare Frugoni" Internal and Geriatric Medicine and Memory Unit, University of Bari "Aldo Moro", Bari, Italy.;Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. ^[2] Unit of Statistics and Epidemiology, Local Health Authority of Taranto, Taranto, Italy. ^[3] Department of Translational Biomedicine and Neuroscience "DiBrain", University of Bari Aldo Moro, Bari, Italy. ^[4] Psychiatric Unit, Department of Clinical & Experimental Medicine, University of Foggia, Foggia, Italy. ^[5] Department of Neuroscience, Catholic University of Sacred Heart, Rome, Italy.;Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy. ^[6] Translational Medicine and Health System Management, Department of Economy, University of Foggia, Foggia, Italy. ^[7]

关键词 Alzheimer’s disease amyloid-β disease-modifying drugs mild cognitive impairment monoclonal antibodies tau protein

医学主题词阿尔茨海默病(Alzheimer Disease);人类(Humans);淀粉样β肽类(Amyloid beta-Peptides);抗体, 单克隆(Antibodies, Monoclonal);动物(Animals);随机对照试验(主题)(Randomized Controlled Trials as Topic);分子靶向治疗(Molecular Targeted Therapy)

DOI 10.1080/14712598.2025.2463963

PMID 39908579

发布时间 2025-05-06

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