Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity.

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第一作者： Cheng,Li

第一单位： State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China; Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.

作者： Cheng,Li ^[1] ; Sha,Cheng ^[2] ; Jia,Yu ^[2] ; Qian,Zheng ^[3] ; Gang,Yu ^[2] ; Mei,Xu ^[2] ; Xueling,Meng ^[2] ; Xiaoping,Zeng ^[2] ; Kun,Liu ^[2] ; Bixue,Xu ^[4] ; Heng,Luo ^[5] ; Guangcan,Xu ^[6]

作者单位： State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China; Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China. ^[1] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. ^[2] Department of Nephrology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China. ^[3] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. Electronic address: bixue_xu@126.com. ^[4] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. Electronic address: luo_heng@gmc.edu.cn. ^[5] State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China. Electronic address: xgc0707@163.com. ^[6]

关键词 4-Trifluoromethylquinoline Anti-prostate cancer Hinge region Molecular docking SGK1 inhibitors Structural optimization

DOI 10.1016/j.ejmech.2025.117336

PMID 39908792

发布时间 2025-02-05

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European journal of medicinal chemistry

2025年287卷

117336页

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Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

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