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Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development.

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作者单位: Institute of Medical Virology, University of Zurich (UZH), 8057 Zurich, Switzerland. [1] Institute of Medical Virology, University of Zurich (UZH), 8057 Zurich, Switzerland; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich (USZ), 8091 Zurich, Switzerland. [2] Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. [3] Department of Biological Sciences, School of Science, University of Eldoret, 30100 Eldoret, Kenya; Institute for Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service, 7925 Cape Town, South Africa. [4] Institute for Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service, 7925 Cape Town, South Africa. [5] Laboratory of Virology, University Hospital Geneva, University of Geneva, 1205 Geneva, Switzerland. [6] Clinical Virology, University Hospital Basel, 4031 Basel, Switzerland. [7] Division of Immunology and Allergy, University Hospital Lausanne, University of Lausanne, 1011 Lausanne, Switzerland. [8] Institute for Infectious Diseases, University of Bern, 3001 Bern, Switzerland. [9] Centre for Laboratory Medicine, 9008 St. Gallen, Switzerland. [10] Institute of Laboratory Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. [11] Department of Microbiology at the University of Washington, Seattle, WA 98195, USA. [12] Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. [13] Department of Medicine, Division of Infectious Diseases, Emory University, Atlanta, GA 30322, USA. [14] University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe; University of California, San Francisco, San Francisco, CA 94115, USA. [15] Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, 4041 Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, 4013 Durban, South Africa. [16] Institute for Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service, 7925 Cape Town, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, 4013 Durban, South Africa. [17] SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2050 Johannesburg, South Africa; National Institute for Communicable Disease of the National Health Laboratory Services, 2192 Johannesburg, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, 4013 Durban, South Africa. [18] Institute of Medical Virology, University of Zurich (UZH), 8057 Zurich, Switzerland. Electronic address: trkola.alexandra@virology.uzh.ch. [19]
DOI 10.1016/j.chom.2025.01.004
PMID 39909038
发布时间 2025-02-05
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