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首页> Proceedings of the National Academy of Sciences of the United States of America> HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.

HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.

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第一作者： Soneya,Majumdar

第一单位： Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12237.

作者： Soneya,Majumdar ^[1] ; Amuliya,Kashyap ^[2] ; Ravi K,Koripella ^[1] ; Manjuli R,Sharma ^[1] ; Kelley,Hurst-Hess ^[2] ; Swati R,Manjari ^[1] ; Nilesh K,Banavali ^[3] ; Pallavi,Ghosh ^[4] ; Rajendra K,Agrawal ^[3]

作者单位： Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12237. ^[1] Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208. ^[2] Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12237.;Department of Biomedical Sciences, University at Albany, Albany, NY 12208. ^[3] Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208.;Department of Biomedical Sciences, University at Albany, Albany, NY 12208. ^[4]

关键词 50S subunit inactivation antibiotic resistance cryo-EM mycobacterial HflX structure of mycobacterial ribosome-HflX complex

主题词 RNA, 核糖体, 23S(RNA, Ribosomal, 23S);核糖体(Ribosomes);冷冻电子显微镜检查(Cryoelectron Microscopy);抗药性, 细菌(Drug Resistance, Bacterial);细菌蛋白质类(Bacterial Proteins);抗菌药(Anti-Bacterial Agents);分枝杆菌属(Mycobacterium);结核分枝杆菌(Mycobacterium tuberculosis);RNA, 核糖体(RNA, Ribosomal);GTP磷酸水解酶类(GTP Phosphohydrolases);核糖体亚单位, 大, 细菌(Ribosome Subunits, Large, Bacterial)

DOI 10.1073/pnas.2419826122

PMID 39913204

发布时间 2025-02-19

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2025年122卷6期

e2419826122页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2025年122卷6期

e2419826122页

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