Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research.

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第一作者： Tian,Tian

第一单位： Medical Big Data and Bioinformatics Research Centre, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.;School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.

作者： Tian,Tian ^[1] ; Guie,Lai ^[2] ; Ming,He ^[3] ; Xiaofang,Liu ^[1] ; Yun,Luo ^[3] ; You,Guo ^[3] ; Guini,Hong ^[4] ; Hongdong,Li ^[4] ; Kai,Song ^[5] ; Hao,Cai ^[6]

作者单位： Medical Big Data and Bioinformatics Research Centre, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.;School of Public Health and Health Management, Gannan Medical University, Ganzhou, China. ^[1] Breast Disease Comprehesive Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. ^[2] Medical Big Data and Bioinformatics Research Centre, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. ^[3] School of Medical Information Engineering, Gannan Medical University, Ganzhou, China. ^[4] School of Medical Information Engineering, Gannan Medical University, Ganzhou, China. songkai_hmu@hotmail.com. ^[5] Medical Big Data and Bioinformatics Research Centre, First Affiliated Hospital of Gannan Medical University, Ganzhou, China. caihao093@163.com. ^[6]

关键词 Biomarker Gene expression Measurement variation Pre-analytical variables Relative expression orderings Robustness

主题词人类(Humans);肿瘤(Neoplasms);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)

DOI 10.1038/s41598-025-88756-0

PMID 39915608

发布时间 2025-02-10

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