Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer's Disease.

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作者： Anna Flavia,Cantone ^[1] ; Chiara,Burgaletto ^[1] ; Giulia,Di Benedetto ^[2] ; Gabriella,Gaudio ^[1] ; Cesarina,Giallongo ^[3] ; Rosario,Caltabiano ^[4] ; Giuseppe,Broggi ^[4] ; Carlo Maria,Bellanca ^[5] ; Giuseppina,Cantarella ^[1] ; Renato,Bernardini ^[5]

作者单位： Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy. ^[1] Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy. giulia.dibenedetto@unict.it.;Clinical Toxicology Unit, University Hospital of Catania, Catania, Italy. giulia.dibenedetto@unict.it. ^[2] Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Division of Hematology, University of Catania, Catania, Italy. ^[3] Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, Catania, Italy. ^[4] Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy.;Clinical Toxicology Unit, University Hospital of Catania, Catania, Italy. ^[5]

关键词 CNS-resident innate immunocytes Cytokines Immune exhaustion Immune response Neuroinflammation Splenocytes