首页> Drug metabolism and disposition: the biological fate of chemicals> Deciphering the cell type-specific and zonal distribution of drug-metabolizing enzymes, transporters, and transcription factors in livers of mice using single-cell transcriptomics.

Deciphering the cell type-specific and zonal distribution of drug-metabolizing enzymes, transporters, and transcription factors in livers of mice using single-cell transcriptomics.

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第一作者： Joe Jongpyo,Lim

第一单位： Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington; Environmental Health and Microbiome Research Center (EHMBRACE), Seattle, Washington.

作者： Joe Jongpyo,Lim ^[1] ; Curtis Dean,Klaassen ^[2] ; Julia Yue,Cui ^[3]

作者单位： Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington; Environmental Health and Microbiome Research Center (EHMBRACE), Seattle, Washington. ^[1] Department of Pharmacology, Toxicology, and Therapeutics, School of Medicine, University of Kansas, Kansas City, Kanas. Electronic address: curtisklaassenphd@gmail.com. ^[2] Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington; Environmental Health and Microbiome Research Center (EHMBRACE), Seattle, Washington. Electronic address: juliacui@uw.edu. ^[3]

关键词 Drug metabolizing enzymes Liver cell types Single cell RNA-sequencing Spatial deconvolution Systems biology