Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade.

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第一作者： Xiaolin,Liu

第一单位： State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.;Department of Neurosurgery, Xijing Hospital, Xi'an, China.

作者： Xiaolin,Liu ^[1] ; Xiao,Liu ^[2] ; Xiaonan,Luo ^[3] ; Maorong,Zhu ^[4] ; Nannan,Liu ^[5] ; Juan,Li ^[2] ; Qi,Zhang ^[2] ; Cheng,Zou ^[4] ; Yuxin,Wu ^[4] ; Zhengcong,Cao ^[4] ; Shuangxin,Ma ^[4] ; Weizhong,Wang ^[2] ; Guangzhao,Yang ^[2] ; Jintao,Gu ^[4] ; Wei,Liu ^[2] ; Meng,Li ^[4] ; Anan,Yin ^[6] ; Yalong,He ^[7] ; Wei,Lin ^[8]

作者单位： State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.;Department of Neurosurgery, Xijing Hospital, Xi'an, China. ^[1] Department of Neurosurgery, Xijing Hospital, Xi'an, China. ^[2] School of Basic Medicine, The Fourth Military Medical University, Xi'an, China. ^[3] State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China. ^[4] Department of Plastic and Reconstructive Surgery, Xijing Hospital, Xi'an, China. ^[5] Department of Plastic and Reconstructive Surgery, Xijing Hospital, Xi'an, China. yinanan@aliyun.com. ^[6] Department of Neurosurgery, Xijing Hospital, Xi'an, China. heyl.fmmu@hotmail.com. ^[7] Department of Neurosurgery, Xijing Hospital, Xi'an, China. linwei@fmmu.edu.cn.;Department of Aviation Medicine, Xijing Hospital, Xi'an, China. linwei@fmmu.edu.cn. ^[8]

关键词 All-in-one CRISPR/Cas9 Gene editing Glioblastoma Immunotherapy

主题词胶质母细胞瘤(Glioblastoma);动物(Animals);人类(Humans);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);小鼠(Mice);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes)

DOI 10.1186/s12951-025-03112-8

PMID 39920725

发布时间 2025-02-10

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