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Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity.

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第一作者： Da-Hye,Jeong

第一单位： Department of Biochemistry, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.;Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea.

作者： Da-Hye,Jeong ^[1] ; Seokhwi,Kim ^[2] ; Han-Hee,Park ^[1] ; Kyoung-Jin,Woo ^[3] ; Jae-Il,Choi ^[4] ; Minji,Choi ^[5] ; Jisoo,Shin ^[5] ; So Hyun,Park ^[4] ; Myung-Wook,Seon ^[1] ; Dakeun,Lee ^[2] ; Jong-Ho,Cha ^[6] ; You-Sun,Kim ^[1]

作者单位： Department of Biochemistry, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.;Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea. ^[1] Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea.;Department of Pathology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. ^[2] Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea. ^[3] Department of Pathology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. ^[4] Program in Biomedical Science and Engineering, Graduate school, Inha University, Incheon, 22212, Republic of Korea. ^[5] Program in Biomedical Science and Engineering, Graduate school, Inha University, Incheon, 22212, Republic of Korea.;Department of Biomedical Sciences, College of Medicine, Inha University, Incheon, 22212, Republic of Korea.;Biohybrid Systems Research Center, Inha University, Incheon, 22212, Republic of Korea. ^[6]

关键词 MLKL RIPK3 immunotherapy necroptosis optogenetics organoid