首页> Bioorganic & medicinal chemistry> Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus.

Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus.

导出 LinkOut

翻译打印收藏纠错

第一作者： Lorenz,Beckmann

第一单位： Institute for Drug Discovery, Faculty of Medicine, Leipzig University 04103 Leipzig, Germany.

作者： Lorenz,Beckmann ^[1] ; Fabian,Liessmann ^[2] ; Maik,Icker ^[3] ; Dominic,Rieger ^[1] ; Phillip,Schlegel ^[1] ; Nicole,Urban ^[4] ; Michael,Schaefer ^[4] ; Jens,Meiler ^[5] ; Clara T,Schoeder ^[6] ; Maik,Tretbar ^[7]

作者单位： Institute for Drug Discovery, Faculty of Medicine, Leipzig University 04103 Leipzig, Germany. ^[1] Institute for Drug Discovery, Faculty of Medicine, Leipzig University 04103 Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University 04105 Leipzig, Germany. ^[2] Institute for Organic Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University 04103 Leipzig, Germany. ^[3] Rudolf-Boehm Institute for Pharmacology and Toxicology, Faculty of Medicine, Leipzig University 04107 Leipzig, Germany. ^[4] Institute for Drug Discovery, Faculty of Medicine, Leipzig University 04103 Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University 04105 Leipzig, Germany; Institute for Computer Science, Wilhelm Ostwald Institute for Physical and Theoretical Chemistry, Leipzig University, Leipzig, Germany; School of Embedded Composite Artificial Intelligence SECAI, Dresden/Leipzig, Germany; Department of Chemistry, Department of Pharmacology, Center for Structural Biology, Institute of Chemical Biology, Center for Applied Artificial Intelligence in Protein Dynamics, Vanderbilt University, Nashville, TN, United States of America. ^[5] Institute for Drug Discovery, Faculty of Medicine, Leipzig University 04103 Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University 04105 Leipzig, Germany. Electronic address: Clara.Schoeder@medizin.uni-leipzig.de. ^[6] Institute for Drug Discovery, Faculty of Medicine, Leipzig University 04103 Leipzig, Germany. Electronic address: maik.tretbar@uni-leipzig.de. ^[7]

关键词 1H-Tetrazoles 2-Aminothiazole Crimean-Congo hemorrhagic fever Deubiquitinase inhibitor Ovarian tumor protease Viral diseases