Prioritizing effector genes at trait-associated loci using multimodal evidence.

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作者： Marijn,Schipper ^[1] ; Christiaan A,de Leeuw ^[2] ; Bernardo A P C,Maciel ^[2] ; Douglas P,Wightman ^[2] ; Nikki,Hubers ^[3] ; Dorret I,Boomsma ^[4] ; Michael C,O'Donovan ^[5] ; Danielle,Posthuma ^[6]

作者单位： Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. m.j.schipper@vu.nl. ^[1] Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. ^[2] Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Amsterdam Reproduction & Development (AR&D) research institute, Amsterdam, The Netherlands. ^[3] Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Amsterdam Reproduction & Development (AR&D) research institute, Amsterdam, The Netherlands. ^[4] Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, Cardiff, UK. ^[5] Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. ^[6]

主题词全基因组关联研究(Genome-Wide Association Study);人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);数量性状基因座位(Quantitative Trait Loci);疾病遗传易感性(Genetic Predisposition to Disease);精神分裂症(Schizophrenia)

DOI 10.1038/s41588-025-02084-7

PMID 39930082

发布时间 2025-02-12

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