MiR-3664-3p through suppressing <i>ABCG2, CYP3A4, MCL1,</i> and <i>MLH1</i> increases the sensitivity of colorectal cancer cells to irinotecan.

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第一作者： Elham,Farrokhnazar

第一单位： Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.;Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Iran.;Department of Molecular Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

作者： Elham,Farrokhnazar ^[1] ; Sahar,Moghbelinejad ^[2] ; Reza,Najafipour ^[3] ; Ladan,Teimoori-Toolabi ^[4]

作者单位： Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.;Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Iran.;Department of Molecular Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. ^[1] Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. ^[2] Genetics Research Center, University of Social Welfare and Rehabilitation Science, Tehran, Iran. ^[3] Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Iran. ^[4]

关键词 ATP Binding Cassette Transporter Colorectal Neoplasm Cytochrome P-450 CYP3A4 Drug Resistance Irinotecan MCL1?protein, human MutL Protein Homolog 1 Subfamily G, Member 2 microRNA, human

DOI 10.1016/j.heliyon.2025.e41933

PMID 39931465

发布时间 2025-02-12

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MiR-3664-3p through suppressing <i>ABCG2, CYP3A4, MCL1,</i> and <i>MLH1</i> increases the sensitivity of colorectal cancer cells to irinotecan.

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MiR-3664-3p through suppressing <i>ABCG2, CYP3A4, MCL1,</i> and <i>MLH1</i> increases the sensitivity of colorectal cancer cells to irinotecan.

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