Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.

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作者： Amy L,Funk ^[1] ; Meghri,Katerji ^[1] ; Marwa,Afifi ^[2] ; Katherine,Nyswaner ^[1] ; Carolyn C,Woodroofe ^[3] ; Zoe C,Edwards ^[4] ; Eric,Lindberg ^[3] ; Knickole L,Bergman ^[1] ; Nancy R,Gough ^[5] ; Maxine R,Rubin ^[1] ; Kamila,Karpińska ^[6] ; Eleanor W,Trotter ^[4] ; Sweta,Dash ^[1] ; Amy L,Ries ^[7] ; Amy,James ^[7] ; Christina M,Robinson ^[7] ; Simone,Difilippantonio ^[7] ; Baktiar O,Karim ^[8] ; Ting-Chia,Chang ^[9] ; Li,Chen ^[9] ; Xin,Xu ^[10] ; James H,Doroshow ^[10] ; Ivan,Ahel ^[11] ; Anna A,Marusiak ^[6] ; Rolf E,Swenson ^[3] ; Steven D,Cappell ^[2] ; John,Brognard ^[1]

作者单位： Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA. ^[1] Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. ^[2] Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, NIH, Rockville, MD 20850, USA. ^[3] Cell Division Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. ^[4] BioSerendipity, LLC, Elkridge, MD 21075, USA. ^[5] Laboratory of Molecular OncoSignalling, IMol Polish Academy of Sciences, Warsaw, Poland. ^[6] Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. ^[7] Molecular Histopathology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. ^[8] Molecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. ^[9] Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, MD 20850, USA. ^[10] Sir William Dunn School of Pathology, Oxford OX1 3RE, UK. ^[11]