首页> Biochimica et biophysica acta. Molecular basis of disease> Ncl liquid-liquid phase separation and SUMOylation mediate the stabilization of HIF-1α expression and promote pyroptosis in ischemic hindlimb.

Ncl liquid-liquid phase separation and SUMOylation mediate the stabilization of HIF-1α expression and promote pyroptosis in ischemic hindlimb.

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第一作者： Yanli,Wang

第一单位： Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215123, PR China.

作者： Yanli,Wang ^[1] ; Weiliang,Wu ^[1] ; Yan,Xu ^[2] ; Chengjie,Wu ^[1] ; Qingfang,Han ^[1] ; Tonggan,Lu ^[1] ; Huiling,Zhang ^[1] ; Lijuan,Jiao ^[1] ; Yu,Zhang ^[1] ; Bin,Liu ^[3] ; Xi-Yong,Yu ^[4] ; Yangxin,Li ^[5]

作者单位： Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215123, PR China. ^[1] Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. ^[2] Department of Cardiology, the Second Hospital of Jilin University, Changchun, Jilin 130041, PR China. ^[3] NMPA Key Laboratory for Clinical Research and Evaluation of Drug for Thoracic Diseases, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China. ^[4] Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215123, PR China. Electronic address: yangxin_li@yahoo.com. ^[5]

关键词 HIF-1α LLPS NLRP3 inflammasome Ncl SUMOylation