首页> Journal for immunotherapy of cancer> 4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models.

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models.

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第一作者： Eneko,Garate-Soraluze

第一单位： Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.

作者： Eneko,Garate-Soraluze ^[1] ; Irantzu,Serrano-Mendioroz ^[1] ; Leticia,Fernández-Rubio ^[1] ; Carlos E,De Andrea ^[2] ; Celia,Barrio-Alonso ^[3] ; Claudia Del Pilar,Herrero ^[2] ; Alvaro,Teijeira ^[1] ; Carlos,Luri-Rey ^[1] ; Christina,Claus ^[4] ; Tamara,Tanos ^[4] ; Christian,Klein ^[4] ; Pablo,Umana ^[4] ; Antonio,Rullan ^[5] ; Jon Ander,Simón ^[6] ; María,Collantes ^[6] ; Paloma,Sánchez-Mateos ^[3] ; Ignacio,Melero ^[7] ; Maria E,Rodriguez-Ruiz ^[8]

作者单位： Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain. ^[1] Department of Pathology, Cancer Center Clinica Universidad de Navarra, Pamplona, Spain. ^[2] Department of Immunology, Hospital Gregorio Marañon, Madrid, Madrid, Spain. ^[3] Roche Innovation Centre Zurich, Roche Pharma Research and Early Development (pRED), Schlieren, Switzerland. ^[4] Institute of Immunology and Transplantation, University College London, London, UK. ^[5] Department of Nuclear Medicine, Clinica Universidad de Navarra, Pamplona, Spain. ^[6] Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.;Nuffield Department of Medicine, University of Oxford, Oxford, UK.;Departments of Immunology-Immunotherapy and Radiation Oncology, Cancer Center Clinica Universidad de Navarra, Pamplona, Navarra, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.;Institute for Health Research (IDISNA), Pamplona, Spain. ^[7] Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain mrruiz@unav.es.;Departments of Immunology-Immunotherapy and Radiation Oncology, Cancer Center Clinica Universidad de Navarra, Pamplona, Navarra, Spain.;Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.;Institute for Health Research (IDISNA), Pamplona, Spain. ^[8]

关键词 Abscopal Monoclonal antibody Radiotherapy/radioimmunotherapy Tumor microenvironment - TME