换一批Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity.
第一作者：
Lukas M,Braun
第一单位：
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.
作者：
Lukas M,Braun [1]
;
Sophie,Giesler [2]
;
Geoffroy,Andrieux [3]
;
Roxane,Riemer [2]
;
Nana,Talvard-Balland [2]
;
Sandra,Duquesne [2]
;
Tamina,Rückert [1]
;
Susanne,Unger [4]
;
Stefanie,Kreutmair [4]
;
Melissa,Zwick [1]
;
Marie,Follo [2]
;
Alina,Hartmann [2]
;
Natascha,Osswald [2]
;
Wolfgang,Melchinger [2]
;
Stefanie,Chapman [2]
;
James A,Hutchinson [5]
;
Sebastian,Haferkamp [6]
;
Leopold,Torster [7]
;
Julian,Kött [7]
;
Christoffer,Gebhardt [7]
;
Dirk,Hellwig [8]
;
Nikolaos,Karantzelis [2]
;
Till,Wallrabenstein [2]
;
Theresa,Lowinus [2]
;
Mehtap,Yücel [2]
;
Niklas,Brehm [2]
;
Justyna,Rawluk [2]
;
Dietmar,Pfeifer [2]
;
Peter,Bronsert [9]
;
Manuel,Rogg [9]
;
Sven,Mattern [10]
;
Mathias,Heikenwälder [11]
;
Stefano,Fusco [12]
;
Nisar P,Malek [12]
;
Stephan,Singer [13]
;
Annette,Schmitt-Graeff [14]
;
Fatih,Ceteci [15]
;
Florian R,Greten [15]
;
Bruce R,Blazar [16]
;
Melanie,Boerries [17]
;
Natalie,Köhler [18]
;
Justus,Duyster [19]
;
Gabriele,Ihorst [20]
;
Silke,Lassmann [9]
;
Philip,Keye [21]
;
Susana,Minguet [22]
;
Dirk,Schadendorf [23]
;
Selma,Ugurel [24]
;
David,Rafei-Shamsabadi [25]
;
Robert,Thimme [26]
;
Peter,Hasselblatt [26]
;
Bertram,Bengsch [27]
;
Christoph,Schell [9]
;
Erika L,Pearce [28]
;
Frank,Meiss [25]
;
Burkhard,Becher [4]
;
Carolin,Funke-Lorenz [24]
;
Jan-Malte,Placke [24]
;
Petya,Apostolova [29]
;
Robert,Zeiser [30]
作者单位：
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.
[1]
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[2]
Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[3]
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
[4]
Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
[5]
Department of Dermatology, University Hospital Regensburg, Regensburg, Germany.
[6]
Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[7]
Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany.
[8]
Institute of Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[9]
Institute of Pathology, University Hospital Tübingen, 72076 Tübingen, Germany.
[10]
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; M3 Research Center, Eberhard Karls University Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany.
[11]
Medizinische Klinik I, Uniklinik Tübingen, Tübingen, Germany.
[12]
Institute of Pathology, University Hospital Tübingen, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany.
[13]
University of Freiburg, Freiburg, Germany.
[14]
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany.
[15]
Department of Pediatrics, Division of Blood & Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN, United States.
[16]
Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and Medical Center - University of Freiburg, Freiburg im Breisgau, Germany.
[17]
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
[18]
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and Medical Center - University of Freiburg, Freiburg im Breisgau, Germany.
[19]
Clinical Trials Unit, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[20]
Eye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[21]
Signalling Research Centres BIOSS and CIBSS, Freiburg. Germany. Department of Synthetic Immunology, Faculty of Biology and Centre for Chronic Immunodeficiency (CCI), Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[22]
Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and German Cancer Consortium (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany; National Center for Tumor Diseases (NCT)-West, Campus Essen, & Research Alliance Ruhr, Research Center One Health, University Duisburg-Essen, Essen, Germany.
[23]
Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and German Cancer Consortium (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany.
[24]
Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[25]
Department of Internal Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[26]
German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and Medical Center - University of Freiburg, Freiburg im Breisgau, Germany; Department of Internal Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
[27]
Department of Oncology, The Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
[28]
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and Medical Center - University of Freiburg, Freiburg im Breisgau, Germany; Department of Oncology, The Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Biomedicine, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland; Division of Hematology, University Hospital Basel, Basel, Switzerland. Electronic address: petya.apostolova@unibas.ch.
[29]
Department of Internal Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and Medical Center - University of Freiburg, Freiburg im Breisgau, Germany; Signalling Research Centres BIOSS and CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany. Electronic address: robert.zeiser@uniklinik-freiburg.de.
[30]
医学主题词
脂联素(Adiponectin);动物(Animals);人类(Humans);小鼠(Mice);女(雌)性(Female);男(雄)性(Male);炎症(Inflammation);肿瘤(Neoplasms);中年人(Middle Aged);结肠炎(Colitis);老年人(Aged);前瞻性研究(Prospective Studies);小鼠, 近交C57BL(Mice, Inbred C57BL)
DOI
10.1016/j.ccell.2025.01.004
PMID
39933899
发布时间
2025-05-12
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Cancer cell
Cancer cell
269-291.e19页
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