sdRNA-D43 derived from small nucleolar RNA snoRD43 improves chondrocyte senescence and osteoarthritis progression by negatively regulating PINK1/Parkin-mediated mitophagy pathway via dual-targeting NRF1 and WIPI2.

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第一作者： Zengfa,Deng

第一单位： Department of Sports Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.;Department of Joint Surgery and Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.;The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.

作者： Zengfa,Deng ^[1] ; Changzhao,Li ^[2] ; Shu,Hu ^[3] ; Yanlin,Zhong ^[4] ; Wei,Li ^[4] ; Zhencan,Lin ^[4] ; Xiaolin,Mo ^[4] ; Ming,Li ^[4] ; Dongliang,Xu ^[5] ; Dianbo,Long ^[6] ; Guping,Mao ^[7] ; Yan,Kang ^[8]

作者单位： Department of Sports Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.;Department of Joint Surgery and Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.;The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. ^[1] Department of Joint Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.;Department of Orthopaedics, General Hospital of Southern Theater Command, Guangzhou, China. ^[2] Department of Joint Surgery and Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.;The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China. ^[3] Department of Sports Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[4] Department of Joint Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. ^[5] Department of Sports Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. longdb@mail2.sysu.edu.cn.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. longdb@mail2.sysu.edu.cn. ^[6] Department of Sports Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. maogp@mail2.sysu.edu.cn.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. maogp@mail2.sysu.edu.cn. ^[7] Department of Sports Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. kangyan2@mail.sysu.edu.cn.;Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. kangyan2@mail.sysu.edu.cn. ^[8]

关键词 Chondrocyte senescence Mitophagy Osteoarthritis sdRNA-D43 snoRNA