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Integrating Spatially-Resolved Transcriptomics Data Across Tissues and Individuals: Challenges and Opportunities.

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第一作者： Boyi,Guo

第一单位： Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.

作者： Boyi,Guo ^[1] ; Wodan,Ling ^[2] ; Sang Ho,Kwon ^[3] ; Pratibha,Panwar ^[4] ; Shila,Ghazanfar ^[4] ; Keri,Martinowich ^[5] ; Stephanie C,Hicks ^[6]

作者单位： Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. ^[1] Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, 10065, USA. ^[2] Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.;Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.;Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. ^[3] School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, 2006, Australia.;Sydney Precision Data Science Centre, University of Sydney, Camperdown, NSW, 2006, Australia.;Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia. ^[4] Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.;Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.;Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.;Johns Hopkins Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, 21218, USA.;Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA. ^[5] Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.;Center for Computational Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.;Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, 21218, USA. ^[6]

关键词 integrative analysis multi‐sample population‐level spatial alignment spatial registration spatially‐resolved transcriptomics

主题词人类(Humans);基因表达谱(Gene Expression Profiling);计算生物学(Computational Biology);算法(Algorithms);动物(Animals);结果可重复性(Reproducibility of Results)

DOI 10.1002/smtd.202401194

PMID 39935130

发布时间 2025-05-26

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2025年9卷5期

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Integrating Spatially-Resolved Transcriptomics Data Across Tissues and Individuals: Challenges and Opportunities.

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