Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling.

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作者： Giuliana,Giamundo ^[1] ; Daniela,Intartaglia ^[1] ; Eugenio,Del Prete ^[2] ; Elena,Polishchuk ^[2] ; Fabrizio,Andreone ^[2] ; Marzia,Ognibene ^[3] ; Sara,Buonocore ^[1] ; Bruno,Hay Mele ^[1] ; Francesco Giuseppe,Salierno ^[2] ; Jlenia,Monfregola ^[2] ; Dario,Antonini ^[1] ; Paolo,Grumati ^[4] ; Alessandra,Eva ^[5] ; Rossella,De Cegli ^[2] ; Ivan,Conte ^[1]

作者单位： Department of Biology, University of Naples Federico II, Naples, Italy. ^[1] Telethon Institute of Genetics and Medicine, Pozzuoli, Italy. ^[2] U.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy. ^[3] Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.;Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. ^[4] Laboratory of Molecular Biology, IRCCS Istituto Giannina Gaslini, Genova, Italy. ^[5]

关键词 EGFR EZRIN TSC complex cell biology endosome lysosome mTORC1

主题词信号传导(Signal Transduction);动物(Animals);内颗粒(Endosomes);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);人类(Humans);细胞支架蛋白质类(Cytoskeletal Proteins);表皮生长因子(Epidermal Growth Factor)

DOI 10.7554/eLife.98523

PMID 39937579

发布时间 2025-02-13

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准确一般字义偏差语意偏离译文作用小提交