Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2.
第一作者:
Serena,Lucotti
第一单位:
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. Electronic address: sel4002@med.cornell.edu.
作者:
Serena,Lucotti [1]
;
Yusuke,Ogitani [2]
;
Candia M,Kenific [2]
;
Jacob,Geri [3]
;
Young Hun,Kim [4]
;
Jinghua,Gu [5]
;
Uthra,Balaji [5]
;
Linda,Bojmar [6]
;
Lee,Shaashua [2]
;
Yi,Song [7]
;
Michele,Cioffi [2]
;
Pernille,Lauritzen [2]
;
Oveen M,Joseph [2]
;
Tetsuhiko,Asao [8]
;
Paul M,Grandgenett [9]
;
Michael A,Hollingsworth [9]
;
Christopher,Peralta [10]
;
Alexandra E,Pagano [10]
;
Henrik,Molina [10]
;
Harry B,Lengel [11]
;
Elizabeth G,Dunne [11]
;
Xiaohong,Jing [12]
;
Madeleine,Schmitter [12]
;
Lucia,Borriello [13]
;
Thomas,Miller [2]
;
Haiying,Zhang [2]
;
Yevgeniy,Romin [4]
;
Katia,Manova [4]
;
Doru,Paul [14]
;
H Lawrence,Remmel [15]
;
Eileen M,O'Reilly [16]
;
William R,Jarnagin [7]
;
David,Kelsen [16]
;
Sharon M,Castellino [17]
;
Lisa,Giulino-Roth [18]
;
David R,Jones [11]
;
John S,Condeelis [19]
;
Virginia,Pascual [2]
;
James B,Bussel [20]
;
Nancy,Boudreau [2]
;
Irina,Matei [2]
;
David,Entenberg [21]
;
Jacqueline F,Bromberg [22]
;
Diane M,Simeone [23]
;
David,Lyden [24]
作者单位:
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. Electronic address: sel4002@med.cornell.edu.
[1]
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
[2]
Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
[3]
Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[4]
Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
[5]
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
[6]
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[7]
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Respiratory Medicine, Juntendo University, Tokyo, Japan.
[8]
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
[9]
Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
[10]
Thoracic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[11]
Department of Surgery, UC San Diego Health, San Diego, CA, USA.
[12]
Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA.
[13]
Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
[14]
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Atossa Therapeutics, Inc., Seattle, WA, USA; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
[15]
Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[16]
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.
[17]
Department of Pediatrics, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.
[18]
Department of Surgery, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Integrated Imaging Program for Cancer Research, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Montefiore Einstein Comprehensive Cancer Center, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Gruss-Lipper Biophotonics Center, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Department of Cell Biology, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Cancer Dormancy Institute, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
[19]
Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA; Department of Pediatrics, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.
[20]
Integrated Imaging Program for Cancer Research, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Montefiore Einstein Comprehensive Cancer Center, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Gruss-Lipper Biophotonics Center, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Department of Cell Biology, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Cancer Dormancy Institute, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; Department of Pathology, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
[21]
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address: bromberj@mskcc.org.
[22]
Department of Surgery, UC San Diego Health, San Diego, CA, USA; Moores Cancer Center, UC San Diego Health, San Diego, CA, USA. Electronic address: dsimeone@ucsd.edu.
[23]
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Drukier Institute for Children's Health and Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. Electronic address: dcl2001@med.cornell.edu.
[24]
DOI
10.1016/j.cell.2025.01.025
PMID
39938515
发布时间
2025-02-12
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