Deaminase-Driven Reverse Transcription Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution Signatures.

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作者： Edward J,Steele ^[1] ; Robyn A,Lindley ^[2]

作者单位： Melville Analytics Pty Ltd. and Immunomics, Kangaroo Point, Brisbane 4169, Australia. ^[1] Department Clinical Pathology, Victorian Comprehensive Cancer Centre (VCCC), University of Melbourne, Melbourne 3052, Australia. ^[2]

关键词 AID/APOBEC and ADAR deaminases COSMIC SBS cancer signatures DNA polymerase eta DNA polymerase theta immunoglobulin somatic hypermutation origin somatic mutations reverse transcription

主题词人类(Humans);肿瘤(Neoplasms);诱变(Mutagenesis);胞苷脱氨酶(Cytidine Deaminase);逆转录作用(Reverse Transcription);体细胞高突变, 免疫球蛋白(Somatic Hypermutation, Immunoglobulin);腺苷脱氨酶(Adenosine Deaminase);突变(Mutation)

DOI 10.3390/ijms26030989

PMID 39940758

发布时间 2025-02-13

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International journal of molecular sciences

2025年26卷3期

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Deaminase-Driven Reverse Transcription Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution Signatures.

International journal of molecular sciences

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International journal of molecular sciences

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Deaminase-Driven Reverse Transcription Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution Signatures.

International journal of molecular sciences

相似文献

International journal of molecular sciences

相关期刊

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