Triazole-Estradiol Analogs Induce Apoptosis and Inhibit EGFR and Its Downstream Pathways in Triple Negative Breast Cancer.

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第一作者： Felix,Acheampong

第一单位： Department of Preclinical Pharmacology and Toxicology, Verve Therapeutics Inc., Boston, MA 02215, USA.;Department of Chemistry and Biochemistry, College of Natural Sciences, South Dakota State University, Brookings, SD 57007, USA.

作者： Felix,Acheampong ^[1] ; Trevor,Ostlund ^[2] ; Emily,Hedge ^[2] ; Jacqueline,Laddusaw ^[2] ; Faez,Alotaibi ^[3] ; Yaseen A M M,Elshaier ^[4] ; Fathi,Halaweish ^[2]

作者单位： Department of Preclinical Pharmacology and Toxicology, Verve Therapeutics Inc., Boston, MA 02215, USA.;Department of Chemistry and Biochemistry, College of Natural Sciences, South Dakota State University, Brookings, SD 57007, USA. ^[1] Department of Chemistry and Biochemistry, College of Natural Sciences, South Dakota State University, Brookings, SD 57007, USA. ^[2] Department of Chemistry and Biochemistry, College of Natural Sciences, South Dakota State University, Brookings, SD 57007, USA.;Department of Chemistry, College of Science, Qassim University, Buraydah 51452, Saudi Arabia. ^[3] Department of Chemistry and Biochemistry, College of Natural Sciences, South Dakota State University, Brookings, SD 57007, USA.;Department of Organic and Medicinal Chemistry, University of Sadat City, Monufia 32897, Egypt. ^[4]

关键词 apoptosis epidermal growth factor receptor molecular dynamic simulations triazole analogs triple negative breast cancer