Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer.

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第一作者： Jindi,Huang

第一单位： Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.

作者： Jindi,Huang ^[1] ; Ya,He ^[1] ; Sumeng,Chen ^[1] ; Ran,Ren ^[2] ; Shipeng,Zhang ^[1] ; Ji-Quan,Zhang ^[3] ; Zhang,Zhang ^[4] ; Tie-Gen,Chen ^[5] ; Ling,Wang ^[6]

作者单位： Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China. ^[1] International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, 510632, China. ^[2] College of Pharmacy, Guizhou Medical University, Guiyang, 550004, China. ^[3] International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, 510632, China. Electronic address: zzmoxue@163.com. ^[4] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. Electronic address: chentiegen@simm.ac.cn. ^[5] Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, Joint International Research Laboratory of Synthetic Biology and Medicine, Guangdong Provincial Engineering and Technology Research Center of Biopharmaceuticals, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China. Electronic address: lingwang@scut.edu.cn. ^[6]

关键词 CDK9 Cancer Dual inhibitor PARP Pharmacophore-fusion