首页> Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology> On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy.

On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy.

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第一作者： Yolanda,Prezado

第一单位： New Approaches in Radiotherapy Lab, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, A Coruña 15706, Spain; Oportunius Program, Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, A Coruña, Spain; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France. Electronic address: Yolanda.prezado@usc.es.

作者： Yolanda,Prezado ^[1] ; Charlotte,Lamirault ^[2] ; Thibaut,Larcher ^[3] ; Cristele,Gilbert ^[4] ; Julie,Espenon ^[4] ; A,Patriarca ^[5] ; L,de Marzi ^[6] ; Angela,Corvino ^[4] ; Ramon,Ortiz ^[4] ; Marjorie,Juchaux ^[4]

作者单位： New Approaches in Radiotherapy Lab, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, A Coruña 15706, Spain; Oportunius Program, Galician Agency of Innovation (GAIN), Xunta de Galicia, Santiago de Compostela, A Coruña, Spain; Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France. Electronic address: Yolanda.prezado@usc.es. ^[1] Translational Research Department, Institut Curie, Experimental Radiotherapy Platform, Université Paris Saclay, 91400 Orsay, France. ^[2] UMR703 - PAnTher - APEX, Oniris, Nantes, France. ^[3] Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France. ^[4] Institut Curie, Radiation Oncology Department, Campus universitaire, 91898 Orsay, France. ^[5] Institut Curie, Radiation Oncology Department, Campus universitaire, 91898 Orsay, France; Institut Curie, Université PSL, Université Paris-Saclay, Inserm U1288, Laboratoire de Recherche Translationnelle en Oncologie (LITO), 91898 Orsay, France. ^[6]

关键词 Normal tissue sparing Peak dose Spatially fractionated radiation therapy

医学主题词动物(Animals);大鼠(Rats);脑(Brain);男(雄)性(Male);放射治疗剂量(Radiotherapy Dosage);剂量效应关系, 辐射(Dose-Response Relationship, Radiation)

DOI 10.1016/j.radonc.2025.110769

PMID 39947329

发布时间 2026-04-04

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