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PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice.

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第一作者： Qian,Zhao

第一单位： NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 China.

作者： Qian,Zhao ^[1] ; Chunyuan,Zeng ^[1] ; Fulan,Luo ^[1] ; Zihong,Xian ^[1] ; Huizhen,Wen ^[1] ; Xingxing,Tu ^[1] ; Rifang,Yang ^[2] ; Yijun,Sun ^[1] ; Xiangling,Zheng ^[1] ; Jiangping,Xu ^[3] ; Haitao,Wang ^[4]

作者单位： NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 China. ^[1] Research and Development Department, Lansson Bio-Pharm Co., Ltd., Suzhou, China. ^[2] NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 China; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou 510515 China. Electronic address: jpx@smu.edu.cn. ^[3] NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 China; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou 510515 China. Electronic address: wht821@smu.edu.cn. ^[4]

关键词 C1q/C3 Complement HMGB1 Microglial activation PDE4 Synaptic pruning