首页> The Journal of pharmacology and experimental therapeutics> First-in-class mitogen-activated protein kinase (MAPK) p38α: MAPK-activated protein kinase 2 dual signal modulator with anti-inflammatory and endothelial-stabilizing properties.

First-in-class mitogen-activated protein kinase (MAPK) p38α: MAPK-activated protein kinase 2 dual signal modulator with anti-inflammatory and endothelial-stabilizing properties.

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第一作者： Mohan E,Tulapurkar

第一单位： Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: mtulapurkar@som.umaryland.edu.

作者： Mohan E,Tulapurkar ^[1] ; Kari Ann,Shirey ^[2] ; Katerina,Lugkey ^[3] ; Wendy,Luo ^[4] ; Ritu,Lal ^[4] ; Adam,Galan ^[4] ; Omar,Mahmoud ^[5] ; Nathaniel,McClean ^[6] ; Kiruphagaran,Thangaraju ^[7] ; Daniel,Cericola ^[8] ; Daniel,Lewis ^[8] ; William A,Murphy ^[8] ; Steven,Fletcher ^[8] ; Alexander D,MacKerell ^[8] ; Stefanie N,Vogel ^[2] ; Paul,Shapiro ^[9] ; Jeffrey D,Hasday ^[10]

作者单位： Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: mtulapurkar@som.umaryland.edu. ^[1] Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland. ^[2] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Medicine and Research Services of the Baltimore VA Medical Center, Baltimore, Maryland. ^[3] GEn1E Lifesciences, Palo Alto, California. ^[4] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland. ^[5] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland. ^[6] Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland. ^[7] Medicine and Research Services of the Baltimore VA Medical Center, Baltimore, Maryland. ^[8] Medicine and Research Services of the Baltimore VA Medical Center, Baltimore, Maryland. Electronic address: pshapiro@rx.umaryland.edu. ^[9] Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Medicine and Research Services of the Baltimore VA Medical Center, Baltimore, Maryland. Electronic address: jhasday@som.umaryland.edu. ^[10]

关键词 Endothelial barrier function Inflammation MAP kinase-activated protein kinase Signaling p38 MAP kinase

DOI 10.1124/jpet.124.002281

PMID 39969269

发布时间 2025-02-20

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