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M49L and other drug resistance mutations emerging in individuals after administration of ensitrelvir in Japanese clinical settings.

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第一作者： Akira,Inoue

第一单位： Genome Analysis Center, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: inouea@takii.kmu.ac.jp.

作者： Akira,Inoue ^[1] ; Takaya,Ichikawa ^[2] ; Daiki,Wada ^[3] ; Shuhei,Maruyama ^[4] ; Haruka,Shimazu ^[5] ; Masami,Kashihara ^[6] ; Kazuyuki,Okuda ^[7] ; Fukuki,Saito ^[8] ; Takasuke,Fukuhara ^[9] ; Yasushi,Nakamori ^[10]

作者单位： Genome Analysis Center, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: inouea@takii.kmu.ac.jp. ^[1] Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan. Electronic address: ichikawa.takaya.d0@elms.hokudai.ac.jp. ^[2] Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: dk0116-w@live.jp. ^[3] Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: suugakunotiti@gmail.com. ^[4] Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: kukki.lucky.candy@gmail.com. ^[5] Genome Analysis Center, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: kashiham@takii.kmu.ac.jp. ^[6] Genome Analysis Center, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: okudak0217@gmail.com. ^[7] Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: saitof@takii.kmu.ac.jp. ^[8] Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan. Electronic address: fukut@pop.med.hokudai.ac.jp. ^[9] Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Osaka, Japan. Electronic address: nakamory@takii.kmu.ac.jp. ^[10]

关键词 3CL protease inhibiter COVID-19 Ensitrelvir Resistance SARS-CoV-2