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AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification.

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第一作者： LeeAnn A,Hold

第一单位： Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.;Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States.

作者： LeeAnn A,Hold ^[1] ; Nicole,Migotsky ^[2] ; Syeda N,Lamia ^[2] ; Steph S,Steltzer ^[1] ; Sydney,Grossman ^[2] ; Jessica,Chen ^[2] ; Seung-Ho,Bae ^[2] ; Paige,Cordts ^[2] ; Tessa,Phillips ^[3] ; Matthew J,O'Meara ^[4] ; Carol,Davis ^[5] ; Susan V,Brooks ^[6] ; Moeed,Akbar ^[7] ; Neal L,Millar ^[7] ; Megan L,Killian ^[1] ; Adam C,Abraham ^[8]

作者单位： Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.;Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States. ^[1] Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States. ^[2] Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States.;University of Toledo College of Medicine, Toledo, Ohio, United States. ^[3] Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States.;Medicinal Chemistry, University of Michigan, Ann Arbor, MI, United States. ^[4] Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States. ^[5] Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.;Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States. ^[6] Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. ^[7] Orthopedic Surgery, University of Michigan, Ann Arbor, MI, United States.;Lead contact. ^[8]

关键词 AMPKa1 Extracellular matrix Prkaa1 biomechanics exercise senescence

DOI 10.1101/2025.01.31.635920

PMID 39975248

发布时间 2025-09-11

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AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification.

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AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification.

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