首页> Nature communications> Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.

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第一作者： Nathalie,Khoury

第一单位： Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA.

作者： Nathalie,Khoury ^[1] ; Michelle E,Pizzo ^[1] ; Claire B,Discenza ^[1] ; David,Joy ^[1] ; David,Tatarakis ^[1] ; Mihail Ivilinov,Todorov ^[2] ; Moritz,Negwer ^[2] ; Connie,Ha ^[1] ; Gabrielly L,De Melo ^[1] ; Lily,Sarrafha ^[1] ; Matthew J,Simon ^[1] ; Darren,Chan ^[1] ; Roni,Chau ^[1] ; Kylie S,Chew ^[1] ; Johann,Chow ^[1] ; Allisa,Clemens ^[1] ; Yaneth,Robles-Colmenares ^[1] ; Jason C,Dugas ^[1] ; Joseph,Duque ^[1] ; Doris,Kaltenecker ^[2] ; Holly,Kane ^[1] ; Amy,Leung ^[1] ; Edwin,Lozano ^[1] ; Arash,Moshkforoush ^[1] ; Elysia,Roche ^[1] ; Thomas,Sandmann ^[1] ; Mabel,Tong ^[1] ; Kaitlin,Xa ^[1] ; Yinhan,Zhou ^[1] ; Joseph W,Lewcock ^[1] ; Ali,Ertürk ^[2] ; Robert G,Thorne ^[1] ; Meredith E K,Calvert ^[3] ; Y Joy,Yu Zuchero ^[4]

作者单位： Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. ^[1] Deep Piction, 81377, Munich, Germany. ^[2] Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. calvert@dnli.com. ^[3] Denali Therapeutics, Inc., 161 Oyster Point Blvd., South San Francisco, CA, 94080, USA. zuchero@dnli.com. ^[4]