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An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models.

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第一作者： Sonja,Meier

第一单位： Pharma Research and Early Development, Neuroscience and Rare Diseases, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.

作者： Sonja,Meier ^[1] ; Anne Sofie Gry,Larsen ^[2] ; Florian,Wanke ^[1] ; Nicolas,Mercado ^[3] ; Arianna,Mei ^[4] ; Livia,Takacs ^[1] ; Eva Suszanna,Mracsko ^[1] ; Ludovic,Collin ^[1] ; Martin,Kampmann ^[5] ; Filip,Roudnicky ^[6] ; Ravi,Jagasia ^[1]

作者单位： Pharma Research and Early Development, Neuroscience and Rare Diseases, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. ^[1] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, England; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England. ^[2] Pharma Research and Early Development, Immunology and Inflammation, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. ^[3] Pharma Research and Early Development, Therapeutic Modalities, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. ^[4] Department of Biochemistry and Biophysics, Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA 94158, USA. ^[5] Pharma Research and Early Development, Therapeutic Modalities, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. Electronic address: filip.roudnicky@roche.com. ^[6]

关键词 APOE CRISPR-Cas9 gene editing arrayed genetic screening iPSC-derived microglia lipid accumulation lipid droplet screen lipid metabolism lipid regulation lysosome mTORC1