首页> International journal of biological macromolecules> Deep learning-driven semi-rational design in phenylalanine ammonia-lyase for enhanced catalytic efficiency.

Deep learning-driven semi-rational design in phenylalanine ammonia-lyase for enhanced catalytic efficiency.

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第一作者： Xudong,Lü

第一单位： NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.

作者： Xudong,Lü ^[1] ; Shuai,Fan ^[1] ; Ruijie,Lü ^[1] ; Lixia,Zong ^[2] ; Zhiyong,Xia ^[2] ; Yuanyuan,Jin ^[3] ; Zhifeng,Zhang ^[4] ; Zhaoyong,Yang ^[5]

作者单位： NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. ^[1] School of Pharmacy, North China University of Science and Technology, Tangshan 063210, China. ^[2] NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. Electronic address: jinyuanyuan@imb.pumc.edu.cn. ^[3] School of Pharmacy, North China University of Science and Technology, Tangshan 063210, China. Electronic address: zhangzhifeifei7208@163.com. ^[4] NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. Electronic address: zhaoyongy@imb.pumc.edu.cn. ^[5]

关键词 Catalytic efficiency Deep learning Molecular dynamics simulations Phenylalanine ammonia lyase Phenylketonuria