首页> The Journal of clinical investigation> An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma.

An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma.

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第一作者： Annegret,Holm

第一单位： Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

作者： Annegret,Holm ^[1] ; Matthew S,Graus ^[2] ; Jill,Wylie-Sears ^[1] ; Jerry Wei Heng,Tan ^[1] ; Maya,Alvarez-Harmon ^[1] ; Luke,Borgelt ^[1] ; Sana,Nasim ^[1] ; Long,Chung ^[2] ; Ashish,Jain ^[3] ; Mingwei,Sun ^[3] ; Liang,Sun ^[3] ; Pascal,Brouillard ^[4] ; Ramrada,Lekwuttikarn ^[5] ; Yanfei,Qi ^[2] ; Joyce,Teng ^[5] ; Miikka,Vikkula ^[6] ; Harry,Kozakewich ^[7] ; John B,Mulliken ^[8] ; Mathias,Francois ^[9] ; Joyce,Bischoff ^[1]

作者单位： Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[1] The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing, Centenary Institute, University of Sydney, Camperdown, New South Wales, Australia. ^[2] Research Computing, Information Technology, Boston Children's Hospital, Boston, Massachusetts, USA. ^[3] Human Molecular Genetics, de Duve Institute, University of Louvain, VASCERN-VASCA European Reference Center, Brussels, Belgium. ^[4] Department of Dermatology, Lucile Packard Children's Hospital at the Stanford University School of Medicine, Palo Alto, California, USA. ^[5] Human Molecular Genetics, de Duve Institute, University of Louvain, VASCERN-VASCA European Reference Center, Brussels, Belgium.;WELBIO Department, WEL Research Institute, Wavre, Belgium. ^[6] Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[7] Department of Plastic and Oral Surgery, Boston Children's Hospital; Department of Surgery, Harvard Medical School; Boston, Massachusetts, USA. ^[8] The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing, Centenary Institute, University of Sydney, Camperdown, New South Wales, Australia.;School of Biomedical Sciences, University of Sydney, Camperdown, New South Wales, Australia. ^[9]

关键词 Angiogenesis Cholesterol Endothelial cells Transcription Vascular biology