首页> Annals of the rheumatic diseases> A coding single nucleotide polymorphism in the interleukin-6 receptor enhances IL-6 signalling in CD4 T cells and predicts treatment response to tocilizumab in giant cell arteritis.

A coding single nucleotide polymorphism in the interleukin-6 receptor enhances IL-6 signalling in CD4 T cells and predicts treatment response to tocilizumab in giant cell arteritis.

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第一作者： Robert,Zorc

第一单位： National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

作者： Robert,Zorc ^[1] ; Christopher,Redmond ^[1] ; McKella,Sylvester ^[1] ; Mary,Maclean ^[1] ; Luciana,Yamamoto de Almeida ^[1] ; Kaitlin A,Quinn ^[1] ; Alessandro,Tomelleri ^[2] ; Corrado,Campochiaro ^[2] ; Lorenzo,Dagna ^[2] ; Fernanda,Gutierrez-Rodrigues ^[3] ; Kristina V,Wells ^[1] ; Cameron,Rankin ^[1] ; Sabrina Helmold,Hait ^[1] ; Chloe,Palmer ^[1] ; Robert,Corty ^[4] ; Alexander,Bick ^[4] ; Kathi,Lambert ^[5] ; Jane H,Buckner ^[5] ; John J,O'Shea ^[1] ; Jin Kyun,Park ^[6] ; Massimo,Gadina ^[1] ; Peter C,Grayson ^[7]

作者单位： National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. ^[1] Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. ^[2] National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, USA. ^[3] Department of Medicine, Vanderbilt University, Nashville, TN, USA. ^[4] Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA. ^[5] National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA; Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ^[6] National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: peter.grayson@nih.gov. ^[7]