Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer.

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第一作者： Retheesh S,Thankan

第一单位： Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.;Isoprene Pharmaceuticals, Inc., University of Maryland Baltimore BioPark, Baltimore, MD, USA.

作者： Retheesh S,Thankan ^[1] ; Elizabeth,Thomas ^[2] ; Mehari M,Weldemariam ^[3] ; Puranik,Purushottamachar ^[2] ; Weiliang,Huang ^[3] ; Maureen A,Kane ^[3] ; Yuji,Zhang ^[4] ; Nicholas,Ambulos ^[5] ; Bi-Dar,Wang ^[6] ; David,Weber ^[7] ; Vincent C O,Njar ^[8]

作者单位： Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.;Isoprene Pharmaceuticals, Inc., University of Maryland Baltimore BioPark, Baltimore, MD, USA. ^[1] Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.;The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA. ^[2] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA. ^[3] Division of Biostatistics and Bioinformatics, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA. ^[4] Department of Microbiology and Immunology, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA. ^[5] Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD, USA. ^[6] The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA.;Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.;Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. ^[7] Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.;Isoprene Pharmaceuticals, Inc., University of Maryland Baltimore BioPark, Baltimore, MD, USA.;The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA.;Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA. ^[8]

关键词 CYP51A1 cholesterol lanosterol synthase next‐generation galeterone analog prostate cancer thermal proteome profiling

DOI 10.1002/1878-0261.70009

PMID 40007440

发布时间 2025-02-27

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Molecular oncology

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Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer.

Molecular oncology

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Molecular oncology

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Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer.

Molecular oncology

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Molecular oncology

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