Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.

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第一作者： Swee Y,Sharp

第一单位： RNA Biology and Molecular Therapeutics Team, Centre for Cancer Drug Discovery, Institute of Cancer Research, London, SM2 5NG, UK.

作者： Swee Y,Sharp ^[1] ; Marianna,Martella ^[1] ; Sabrina,D'Agostino ^[1] ; Christopher I,Milton ^[1] ; George,Ward ^[2] ; Andrew J,Woodhead ^[3] ; Caroline J,Richardson ^[4] ; Maria G,Carr ^[2] ; Elisabetta,Chiarparin ^[2] ; Benjamin D,Cons ^[2] ; Joseph,Coyle ^[2] ; Charlotte E,East ^[2] ; Steven D,Hiscock ^[2] ; Carlos,Martinez-Fleites ^[2] ; Paul N,Mortenson ^[2] ; Nick,Palmer ^[2] ; Puja,Pathuri ^[2] ; Marissa V,Powers ^[1] ; Susanne M,Saalau ^[2] ; Jeffrey D,St Denis ^[2] ; Kate,Swabey ^[1] ; Mladen,Vinković ^[2] ; Hugh,Walton ^[2] ; Glyn,Williams ^[2] ; Paul A,Clarke ^[5]

作者单位： RNA Biology and Molecular Therapeutics Team, Centre for Cancer Drug Discovery, Institute of Cancer Research, London, SM2 5NG, UK. ^[1] Astex Pharmaceuticals, Cambridge Science Park, Cambridge, CB4 0QA, UK. ^[2] Astex Pharmaceuticals, Cambridge Science Park, Cambridge, CB4 0QA, UK. Andrew.Woodhead@astx.com. ^[3] Astex Pharmaceuticals, Cambridge Science Park, Cambridge, CB4 0QA, UK. Caroline.Richardson@astx.com. ^[4] RNA Biology and Molecular Therapeutics Team, Centre for Cancer Drug Discovery, Institute of Cancer Research, London, SM2 5NG, UK. Paul.Clarke@icr.ac.uk. ^[5]