首页> Journal of medicinal chemistry> Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.

Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.

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第一作者： Jamison B,Tuttle

第一单位： Pfizer Research & Development, Cambridge, Massachusetts 02139, United States.

作者： Jamison B,Tuttle ^[1] ; Christophe,Allais ^[2] ; Charlotte M N,Allerton ^[1] ; Annaliesa S,Anderson ^[3] ; Joel T,Arcari ^[2] ; Lisa M,Aschenbrenner ^[2] ; Melissa,Avery ^[2] ; Justin,Bellenger ^[2] ; Simon,Berritt ^[2] ; Britton,Boras ^[4] ; Brian P,Boscoe ^[2] ; Leanne M,Buzon ^[2] ; Rhonda D,Cardin ^[3] ; Anthony A,Carlo ^[2] ; Karen J,Coffman ^[2] ; Alyssa,Dantonio ^[2] ; Li,Di ^[2] ; Heather,Eng ^[2] ; Kathleen A,Farley ^[2] ; Rose Ann,Ferre ^[4] ; Ketan S,Gajiwala ^[4] ; Scott A,Gibson ^[5] ; Samantha E,Greasley ^[4] ; Brett L,Hurst ^[5] ; Eugene P,Kadar ^[2] ; Amit S,Kalgutkar ^[1] ; Erik A,Lachapelle ^[2] ; Lorraine F,Lanyon ^[2] ; Jisun,Lee ^[2] ; Jack,Lee ^[2] ; Yajing,Lian ^[2] ; Wei,Liu ^[4] ; Luis A,Martínez-Alsina ^[2] ; Stephen W,Mason ^[3] ; Stephen,Noell ^[2] ; Jonathan,Novak ^[1] ; R Scott,Obach ^[2] ; Kevin,Ogilvie ^[2] ; Steven V,O'Neil ^[2] ; Gregory,Ostner ^[2] ; Dafydd R,Owen ^[1] ; Nandini C,Patel ^[1] ; Martin,Pettersson ^[1] ; Ravi Shankar,Singh ^[1] ; Devendra K,Rai ^[2] ; Matthew R,Reese ^[2] ; Sylvie,Sakata ^[4] ; Matthew F,Sammons ^[1] ; Jean G,Sathish ^[3] ; Raman,Sharma ^[2] ; Claire M,Steppan ^[2] ; Al,Stewart ^[4] ; Lawrence,Updyke ^[2] ; Patrick R,Verhoest ^[1] ; Liuqing,Wei ^[2] ; Stephen W,Wright ^[2] ; Eddie,Yang ^[2] ; Qingyi,Yang ^[1] ; Yuao,Zhu ^[3]

作者单位： Pfizer Research & Development, Cambridge, Massachusetts 02139, United States. ^[1] Pfizer Research & Development, Groton, Connecticut 06340, United States. ^[2] Pfizer Research & Development, Pearl River, New York 10965, United States. ^[3] Pfizer Research & Development, La Jolla, California 92121, United States. ^[4] Institute of Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322, United States. ^[5]