Handling missing values in patient-reported outcome data in the presence of intercurrent events.

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第一作者： Doranne,Thomassen

第一单位： Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.

作者： Doranne,Thomassen ^[1] ; Satrajit,Roychoudhury ^[2] ; Cecilie Delphin,Amdal ^[3] ; Dries,Reynders ^[4] ; Jammbe Z,Musoro ^[5] ; Willi,Sauerbrei ^[6] ; Els,Goetghebeur ^[4] ; Saskia,le Cessie ^[7] ; SISAQOL-IMI Work Package 3

作者单位： Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. ^[1] Pfizer Inc, New York, NY, USA. ^[2] Research Support Services, Oslo University Hospital, Oslo, Norway.;Department of Oncology, Oslo University Hospital, Oslo, Norway. ^[3] Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium. ^[4] European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium. ^[5] Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. ^[6] Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. s.le_cessie@lumc.nl.;Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium. s.le_cessie@lumc.nl.;Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. s.le_cessie@lumc.nl. ^[7]

关键词 Estimand Intercurrent event Missing data Multiple imputation Patient-reported outcomes Repeated measurements

主题词人类(Humans);生活质量(Quality of Life);肺肿瘤(Lung Neoplasms);数据说明, 统计(Data Interpretation, Statistical);疾病恶化(Disease Progression);模型, 统计学(Models, Statistical)

DOI 10.1186/s12874-025-02510-8

PMID 40025441

发布时间 2025-03-05

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准确一般字义偏差语意偏离译文作用小提交