首页> The Journal of clinical investigation> Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis.

Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis.

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第一作者： Takashi,Suzuki

第一单位： Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

作者： Takashi,Suzuki ^[1] ; Erik,Loyde ^[1] ; Sara,Chen ^[2] ; Valerie,Etzrodt ^[1] ; Temitayo O,Idowu ^[1] ; Amanda J,Clark ^[3] ; Marie Christelle,Saade ^[1] ; Brenda Mendoza,Flores ^[1] ; Shulin,Lu ^[2] ; Gabriel,Birrane ^[4] ; Vamsidhara,Vemireddy ^[1] ; Benjamin,Seeliger ^[5] ; Sascha,David ^[6] ; Samir M,Parikh ^[7]

作者单位： Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA. ^[1] Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. ^[2] Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.;Division of Pediatric Nephrology, Department of Pediatrics, UT Southwestern Medical Center and Children's Medical Center, Dallas, Texas, USA. ^[3] Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. ^[4] Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.;Biomedical Research in End-Stage and Obstructive Lung Disease, Hannover Medical School, German Center for Lung Research, Hannover, Germany. ^[5] Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland. ^[6] Division of Nephrology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.;Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.;Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, USA. ^[7]

关键词 Endothelial cells Inflammation Vascular biology