Decoding fracture healing: A scoping review of mechanistic pathways derived from transcriptional analysis in murine studies.

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第一作者： Nazanin,Nafisi

第一单位： Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA.

作者： Nazanin,Nafisi ^[1] ; Ahmad Hedayatzadeh,Razavi ^[1] ; Mohammad Javad,Shariyate ^[2] ; Maria V,Velasquez ^[2] ; Mohammad,Khak ^[2] ; David,Manoukian ^[2] ; Arthur,Klujian ^[2] ; Hamid,Mirzamohammadi ^[3] ; Tom,Cummiskey ^[4] ; Mahboubeh R,Rostami ^[5] ; Fatemeh,Mirzamohammadi ^[6] ; Ara,Nazarian ^[7]

作者单位： Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA. ^[1] Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. ^[2] Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medica Sciences, Tehran, Iran. ^[3] Knowledge Services, Beth Israel Lahey Health, Cambridge, MA, USA. ^[4] Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA. ^[5] Department of Orthopedic and Plastic Surgery, Wright State University, Dayton, OH, USA. ^[6] Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA; Department of Orthopaedic Surgery, Yerevan State Medical University, Yerevan, Armenia. Electronic address: anazaria@bidmc.harvard.edu. ^[7]

关键词 Bone repair mechanisms Fracture healing Inflammation and remodeling Mechanistic pathways Murine models RNA sequencing Systems biology approaches Transcriptional pathways

主题词动物(Animals);骨折愈合(Fracture Healing);小鼠(Mice);人类(Humans);信号传导(Signal Transduction)

DOI 10.1016/j.bone.2025.117444

PMID 40032014

发布时间 2025-03-13

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